Surface Modification of Polydimethylsiloxane via Combined Aminolysis and Alcoholysis Generating Cell Adhesive and Antifouling Properties

Polydimethylsiloxane (PDMS) is an elastomeric polymer frequently used as implant material, for flexible tubing and in microfluidic devices. The pronounced hydrophobic surface of this unique material impedes many applications where a good wetting behavior required. Consequentially, various ways modifications have been to introduce new properties. Plasma treatment the most popular technique respect, but not generally applicable, especially if hardly accessible surfaces are be modified. A novel wet-chemistry-based modification scheme yielding amino-functionalized PDMS using combined alcoholysis/aminolysis reaction presented. Biological exemplified by conjugation RGD peptide, or polyethylene glycol (PEG) heparin, with cell-adhesive nonthrombogenic properties, respectively. effect subsequent adhesive peptide tested cell culture. Additionally, two antifouling generated coupling heparin respectively shown improve materials resistance platelet adhesion drastically while simultaneously preventing recovery surface. findings provide versatile means functionalization substrates suitable biomedical applications.